The Controlled Release of Simvastatin from Biomimetic Macrospheres

Joshua Chou; Tomoko Ito; Makoto Otsuka; Besim Ben-Nissan; Bruce Milthorpe

doi:10.4028/www.scientific.net/KEM.529-530.461

Paper Titles

Composite Bioceramics/Polymer Electrospun Scaffolds for Regenerative Medicine
p.441

Development and Characterization of Poly(ε-caprolactone) Reinforced Porous Hydroxyapatite for Bone Tissue Engineering
p.447

Effect of Organic Polymer Addition on the Microstructure of Magnetite-Polymer Hybrid
p.453

Therapeutic Effect of Lipophilic and/or Hydrophilic Zinc Related Compound Injections on Alveolar Bone Mass in Zinc-Deficient Osteoporosis Rats
p.457

The Controlled Release of Simvastatin from Biomimetic Macrospheres
p.461

Coprecipitation of DNA and Calcium Phosphate Using an Infusion Fluid Mixture
p.465

Novel Apatite-Pathogen-Associated Molecular Patterns Adjuvants for Cancer Immune Therapy
p.471

Adsorption of Alendronate onto Biomimetic Apatite Nanocrystals to Develop Drug Carrier Coating for Bone Implants
p.475

FGF-2-Zinc-Apatite Composite Layers on External Fixation Rod for Promoting Cell Activity
p.480

HomeKey Engineering MaterialsKey Engineering Materials Vols. 529-530The Controlled Release of Simvastatin from...

The Controlled Release of Simvastatin from Biomimetic Macrospheres

Abstract:

Simvastatin has been shown to succesfully stimulate bone regeneration and attention has being focussed on developing appropriate delivery carriers for its release. The challenge of deliverying therapeutic concentration of pharmaceutical compunds has being the centre of focus in drug delivery developments. This study examines the in-vivo effects of simvastatin released from β-TCP macrospheres derived from coral exoxskeletons. The results indicates that the controlled release of simvastatin can promote bone formation comparable with direct injection. Furthermore the results showed that the release of simvastatin delivery rates can be controlled by additional coating of an apatite coating. Analysis by CT scans, SEM, amount of new bone formed and mechanical strength tests, showed that by controlling the release of simvastatin bone formation can be stimulated to a therapeutic level.

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Periodical:

Key Engineering Materials (Volumes 529-530)

Pages:

461-464

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.529-530.461

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Online since:

November 2012

Authors:

Joshua Chou, Tomoko Ito, Makoto Otsuka, Besim Ben-Nissan, Bruce Milthorpe

Keywords:

Biomimetic, Controlled Drug Delivery System, Controlled Release, Coral, Osteoporosis, OVX, Simvastatin

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